Brain Tumour / Cancer

Towards Drug Discovery for Brain Tumours: Interaction of Kinins and Tumours at the Blood Brain Barrier Interface.

Authors: Elizabeth Harford-Wright, Kate M. Lewis, and Robert Vink (2011)

Keywords: CNS tumours · glioma · kinins · blood-brain barrier · substance P · bradykinin.


Cytokine-mediated blood brain barrier disruption as a condu itfor cancer/chemotherapy-associated neurotoxicity and cognitivedysfunction

Authors: Hannah R. Wardill, Kimberley A. Mander, Ysabella Z.A. Van Sebille, Rachel J. Gibson, Richard M. Logan, Joanne M. Bowen and Stephen T. Sonis (2016)

Keywords: neurotoxicity · cognitive dysfunction · blood brain barrier · inflammation · chemotherapy-induced gut toxicity


Toll-like receptor 4 signaling: A common biological mechanism of regimen-related toxicities An emerging hypothesis for neuropathy and gastrointestinal toxicity

Authors: Hannah R. Wardill, Ysabella Z.A. Van Sebille, Kimberley A. Mander, Rachel J. Gibson, Richard M. Logan, Joanne M. Bowen, Stephen T. Sonis (2015)

Keywords: Chemotherapy · Neurotoxicity · Neuropathy · Gut toxicity · Toll-like receptor 4 · Glial activation


Advancing Drug Therapy for Brain Tumours: A Current Review of the Pro-inflammatory Peptide Substance P and its Antagonists as Anti-cancer Agents

Authors: Kimberley Mander, Elizabeth Harford-Wright, Kate M. Lewis, and Robert Vink (2014)

Keywords: Blood-brain barrier · CNS tumours · glioma · metastases · substance P · tight junctions


Neurodegeneration: Alzheimer’s, Parkinson’s, Concussion

A substance P mediated pathway contributes to 6-hydroxydopamine induced cell death.

Authors: Emma Thornton, Tuyet Tran, and Robert Vink (2010)

Keywords: Parkinson’s disease · Substance P · Cell death, Organotypic co-culture · Dopaminergic neurone


Stroke & Oedema

A Surgical Model of Permanent and Transient Middle Cerebral Artery Stroke in the Sheep

Authors: Adam J. Wells, Robert Vink, Peter C. Blumbergs, Brian P. Brophy, Stephen C. Helps, Steven J. Knox, Renée J. Turner (2012)

Keywords: ischaemic stroke · large animal model · middle cerebral artery occlusion


Suppression of inflammation in ischemic and hemorrhagic stroke: therapeutic options.

Authors: Timothy J. Kleinig and Robert Vink (2009)

Keywords: cytokines · edema · inflammasome · innate immunity · neuroprotection · therapy · thrombin


Substance P Antagonists as a Novel Intervention for Brain Edema and Raised Intracranial Pressure

Authors: Levon Gabrielian, Stephen C. Helps, Emma Thornton, Renée Turner, Anna Leonard, and Robert Vink (2013).

Keywords: Neurotrauma · Neurokinins · Tachykinins · Neurogenic inflammation · Rat · Sheep


A substance P antagonist improves outcome when administered 4 h after onset of ischaemic stroke

Authors: Renée Turner, Stephen C. Helps, Emma Thornton, Robert Vink (2011).

Keywords: Ischaemic stroke · NK1 tachykinin receptor antagonist · Oedema · Neuropeptides · Neurogenic inflammation


Combined tissue plasminogen activator and an NK1 tachykinin receptor antagonist: an effective treatment for reperfusion injury following acute ischemic stroke in rats.

Authors: Renée Turner & Robert Vink (2012)

Keywords:

ischaemic stroke · NK1 tachykinin receptor antagonist · tissue plasminogen activator · blood brain barrier · neuropeptides · neurogenic inflammation


Implications of MMP9 for Blood Brain Barrier Disruption and Hemorrhagic Transformation Following Ischemic Stroke.

Authors: Renée Turner and Frank Sharp (2016)

Keywords: metalloproteinases (MMP) · blood brain barrier · ischaemic stroke · haemorrhagic transformation · cerebral oedema · neutrophils · tPA


Inhibition of neurogenic inflammation as a novel treatment for ischemic stroke

Authors: Renée Turner and Robert Vink (2007).

Keywords: neurogenic inflammation · ischaemic stroke · cerebral oedema · substance P


NK1 tachykinin receptor treatment is superior to capsaicin pre-treatment in improving functional outcome following acute ischemic stroke.

Authors: Renée Turner and Robert Vink (2014)

Keywords: Neurogenic inflammation · Neuropeptides ·Ischemic stroke · Capsaicin · NK1 tachykinin receptor antagonist


The role of substance P in ischaemic brain injury

Authors: Renée Turner and Robert Vink (2013).

Keywords: substance P · neuropeptides · neurogenic inflammation · cerebral oedema · stroke · tachykinin · blood-brain barrier · cerebral ischaemia


Traumatic Brain & Spinal Cord Injury

The neuroprotective domains of the amyloid precursor protein, in traumatic brain injury, are located in the two growth factor domains.

Authors: Frances Corrigan, Chi Pham, Robert Vink, Peter Blumbergs, Colin Masters, Corinna Van Den Heuvel, and Roberto Cappai (2011)

Keywords: Amyloid precursor protein · Growth factor like domain · E2 domain · sAPPα · Traumatic brain injury


A Substance P Antagonist Reduces Axonal Injury and Improves Neurologic Outcome When Administered Up to 12 Hours after Traumatic Brain Injury.

Authors: James Donkin, Ibolja Cernak, Peter Blumbergs, and Robert Vink (2011)

Keywords: : neurogenic inflammation · neuropeptides · neurotrauma · neurokinin 1 (NK1) antagonist


Substance P Antagonists as a Therapeutic Approach to Improving Outcome Following Traumatic Brain Injury.

Authors: Robert Vink and Corinna Van Den Heuvel (2010)

Keywords: traumatic brain injury · Substance P · neurogenic inflammation · edema · NK1 receptor antagonist


Magnesium in acute and chronic brain injury: an update

Authors: Robert Vink, Naomi Cook, and Corinna Van Den Heuvel (2009)

Keywords: traumatic brain injury · stroke · neurodegeneration · neonatal brain injury · brain magnesium


Are the transient receptor potential melastatin (TRPM) channels important in magnesium homeostasis following traumatic brain injury?

Authors: Naomi Cook, Corinna Van Den Heuvel, and Robert Vink (2009)

Keywords: traumatic brain injury · brain magnesium · TRPM channels · ischaemic cell death


Recent Patents in CNS Drug Discovery: The Management of Inflammation in the Central Nervous System.

Authors: Alan J. Nimmo and Robert Vink (2009)

Keywords: Brain injury · neuroinflammation · cytokines · chemokines · bradykinin · tachykinins.


Validation of Reference Genes for Normalization of Real-Time Quantitative RT-PCR Data in Traumatic Brain Injury.

Authors: Naomi L. Cook, Robert Vink, James J. Donkin. and Corinna Van Den Heuvel (2009)

Keywords: real-time PCR · substance P · quantitation · rats · neurotraum


Prehospital Hypertonic Saline Resuscitation of Patients With Hypotension and Severe Traumatic Brain Injury: A randomised Controlled Trial.

Authors: James Cooper, Paul Myles, Francis McDermott, Lynette Murray, John Laidlaw, Gregory Cooper, Ann Tremayne, Stephen Bernard, and Jennie Ponsford (2004)

Keywords: hypotension · hypertonic saline · traumatic brain injury · neurological outcome


Prehospital Care of the Multiply Injured Patient. The Challenge of Figuring Out What Works.

Author: Roger J. Lewis (2004)

Keywords: prehospital care · hypertonic saline


An investigation using microdialysis into traumatic brain injury (diffuse axonal injury) with and without hypoxia.

Authors: Prof Jeffrey Rosenfeld and A/Prof Cristina Morganti-Kossmann (2004)

Keywords: microdialysis · traumatic brain injury · hypoxia · neuroinflammation · cytokine expression


Inhibition of cyclooxygenase 2 by nimesulide improves cognitive outcome more than motor outcome following diffuse traumatic brain injury in rats.

Authors: Ibolja Cernak, Christine O’Connor and Robert Vink (2002)

Keywords: Neurotrauma · COX · Cognition · Diffuse axonal injury


Activation of Cyclo-Oxygenase-2 contributes to motor and cognitive dysfunction following diffuse traumatic brain injury in rats.

Authors: I Cernak, C O’Connor and R Vink (2000)

Keywords: diffuse axonal injury · neurological outcome · neurotrauma · nimesulide


Tail artery blood flow measured by chronically implanted Doppler ultrasonic probes in unrestrained conscious rats.

Authors: JN Garcia, NP Pedersen, E Nalivaiko, and WW Blessing (2001)

Keywords: skin blood flow · cutaneous blood flow · temperature regulation · stress · anxiety


Cutaneous vascular bed is not involved in arterial pressure changes elicited by increasing or decreasing the activity of inhibitory vasomotor neurons in caudal ventrolateral medulla in rabbits.

Authors: WW Blessing and E Nalivaiko (2000)

Keywords: caudal ventrolateral medulla · vasomotor neurons · arterial pressure


Carotid and cardiopulmonary chemoreceptor activity increases hippocampal theta rhythm in conscious rabbits.

Authors: Ying-Hui Yu and WW Blessing (2000)

Keywords: carotid artery chemoreceptors · phenylbiguanide (PBG) · electroencephalogram (EEG)


Combined Magnesium/Polyethylene Glycol Facilitates the Neuroprotective Effects of Magnesium in Traumatic Brain Injury at a Reduced Magnesium Dose

Authors: Diana Busingye, Renée Turner, Robert Vink (2016)

Keywords: Blood brain barrier · Edema · Magnesium · Neurotrauma · Treatment


Short and Long Term Behavioral and Pathological Changes in a Novel Rodent Model of Repetitive Mild Traumatic Brain Injury

Authors: Kelly McAteer, Frances Corrigan, Emma Thornton. Renée Turner, and Robert Vink (2016).

Keywords: repetitive mild traumatic brain injury (mTBI) · chronic trumatic encephalopathy (CTE) · tau phosphorylation · neuroinflammation


Substance P in traumatic brain injury

Authors: James Donkin, Renée Turner, Islam Hassan, Robert Vink (2007)

Keywords: neurotrauma · traumatic brain injury · edema · neuropeptides


Other: Aneurysms, Arteriovenous Malformation, Brain Haemorrhage, Moyamoya, Vascular Conditions

Nano-hemostats and a Pilot Study of Their Use in a Large Animal Model of Major Vessel Hemorrhage in Endoscopic Skull Base Surgery

Authors: Alistair Jukes, Jae Murphy, Sarah Vreugde, Alkis Psaltis, P. J. Wormald (2016)

Keywords: endoscopic transsphenoidal surgery · hemorrhage control · nano-medicine · pituitary surgery internal carotid artery injury


Magnesium in the Central Nervous System

Edited by Robert Vink and Mihai Nechifor (2012)

This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesium’s involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behaviour.


Automatic Nonsubjective Estimation of Antigen Content Visualized by Immunohistochemistry Using Color Deconvolution

Authors: Stephen Helps, Emma Thornton, Timothy Kleinig, Jim Manavis, and Robert Vink (2012)

Keywords: antigen estimation · color deconvolution · immunohistochemistry · virtual microscopy · brain


Reference genes for normalising gene expression data in collagenase-induced rat intracerebral haemorrhage.

Authors: Naomi L Cook, Timothy Kleinig, Corinna Van Den Heuvel, and Robert Vink (2010)

Keywords: Intracerebral haemorrhage · RT-PCR · gene expression · normalisation · collagenase-induced ICH


Hemoglobin crystals: A pro-inflammatory potential confounder of rat experimental intracerebral hemorrhage.

Authors: Timothy Kleinig, Stephen Helps, Mounir Ghabriel, Jim Manavis, Christopher Leigh, Peter Blumbergs, and Robert Vink (2009)

Keywords: Hemoglobin · Inflammation · Intracerebral haemorrhage